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In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

Identifieur interne : 000243 ( France/Analysis ); précédent : 000242; suivant : 000244

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

Auteurs : Jean Bernard Lekana-Douki [Gabon] ; Jean Bernard Bongui [Gabon] ; Sandrine Lydie Oyegue Liabagui [Gabon] ; Sonya Estelle Zang Edou [Gabon] ; Rafika Zatra [Gabon] ; Ulrich Bisvigou [Gabon] ; Pierre Druilhe [France] ; Jacques Lebibi [Gabon] ; Fousseyni Samba Toure Ndouo [Gabon] ; Maryvonne Kombila [Gabon]

Source :

RBID : Pascal:11-0146176

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English descriptors

Abstract

Aim of the study: As part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in Haut-Ogooué Province, South-East Gabon. Materials and methods: Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on two chloroquine-resistant strains of Plasmodium falciparum (FCB and W2), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. Results: The methanolic extract of Staudtia gabonensis and the dichloromethane extract of Adhatoda latibracteata showed high antiplasmodial activity (IC50 < 1 μg/ml) and low cytotoxicity, with selectivity indexes of about 58.25 and 16.43, respectively. The methanolic extract of Monodora myristica and the dichloromethane extract of Afromomum giganteum also showed promising activity (1 < IC50 < 10 μg/ml) and low cytotoxicity, with selectivity indexes about 15.70 and 12.48, respectively. Dichloromethane extracts of Monodora myristica and Leonotis Africana showed moderate activity (1050<40μg/ml), with selectivity indexes about 6.07 and 28.89, respectively. Both extracts of Culcasia lancifolia had IC50 values of 10-40 μg/ml but high cytotoxicity (selectivity indexes <2.77). The methanolic extract of Dorstenia klaineana had moderate antiplasmodial activity (IC50 around 17 μg/ml) but strong cytotoxicity (0.43 μg/ml), giving a selectivity index of about 0.03. Conclusions: Most extracts of nine selected plants traditionally used to treat malaria in Gabon had interesting antiplasmodial activity in vitro. This supports continued investigations of traditional medicines in the search for new antimalarial agents. The compounds responsible for the observed antiplasmodial effects are under investigation.


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Pascal:11-0146176

Le document en format XML

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<term>Médecine traditionnelle</term>
<term>Gabon</term>
<term>Plasmodium falciparum</term>
<term>Pharmacognosie</term>
<term>Origine végétale</term>
<term>Antiparasitaire</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr">
<term>Gabon</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Plante médicinale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Aim of the study: As part of a project to identify new compounds active on malarial parasites, we tested the in vitro antiplasmodial activity of nine plants traditionally used to treat malaria symptoms in Haut-Ogooué Province, South-East Gabon. Materials and methods: Dichloromethane and methanolic extracts of each plant were tested for their antiplasmodial activity on two chloroquine-resistant strains of Plasmodium falciparum (FCB and W2), based on lactate dehydrogenase activity. Cytotoxicity was assessed with the MTT test on MRC-5 human diploid embryonic lung cells. Results: The methanolic extract of Staudtia gabonensis and the dichloromethane extract of Adhatoda latibracteata showed high antiplasmodial activity (IC
<sub>50</sub>
< 1 μg/ml) and low cytotoxicity, with selectivity indexes of about 58.25 and 16.43, respectively. The methanolic extract of Monodora myristica and the dichloromethane extract of Afromomum giganteum also showed promising activity (1 < IC
<sub>50</sub>
< 10 μg/ml) and low cytotoxicity, with selectivity indexes about 15.70 and 12.48, respectively. Dichloromethane extracts of Monodora myristica and Leonotis Africana showed moderate activity (10<sub>50</sub>
<40μg/ml), with selectivity indexes about 6.07 and 28.89, respectively. Both extracts of Culcasia lancifolia had IC
<sub>50</sub>
values of 10-40 μg/ml but high cytotoxicity (selectivity indexes <2.77). The methanolic extract of Dorstenia klaineana had moderate antiplasmodial activity (IC
<sub>50</sub>
around 17 μg/ml) but strong cytotoxicity (0.43 μg/ml), giving a selectivity index of about 0.03. Conclusions: Most extracts of nine selected plants traditionally used to treat malaria in Gabon had interesting antiplasmodial activity in vitro. This supports continued investigations of traditional medicines in the search for new antimalarial agents. The compounds responsible for the observed antiplasmodial effects are under investigation.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>France</li>
<li>Gabon</li>
</country>
<region>
<li>Île-de-France</li>
</region>
<settlement>
<li>Paris</li>
</settlement>
</list>
<tree>
<country name="Gabon">
<noRegion>
<name sortKey="Lekana Douki, Jean Bernard" sort="Lekana Douki, Jean Bernard" uniqKey="Lekana Douki J" first="Jean Bernard" last="Lekana-Douki">Jean Bernard Lekana-Douki</name>
</noRegion>
<name sortKey="Bisvigou, Ulrich" sort="Bisvigou, Ulrich" uniqKey="Bisvigou U" first="Ulrich" last="Bisvigou">Ulrich Bisvigou</name>
<name sortKey="Bisvigou, Ulrich" sort="Bisvigou, Ulrich" uniqKey="Bisvigou U" first="Ulrich" last="Bisvigou">Ulrich Bisvigou</name>
<name sortKey="Bongui, Jean Bernard" sort="Bongui, Jean Bernard" uniqKey="Bongui J" first="Jean Bernard" last="Bongui">Jean Bernard Bongui</name>
<name sortKey="Edou, Sonya Estelle Zang" sort="Edou, Sonya Estelle Zang" uniqKey="Edou S" first="Sonya Estelle Zang" last="Edou">Sonya Estelle Zang Edou</name>
<name sortKey="Kombila, Maryvonne" sort="Kombila, Maryvonne" uniqKey="Kombila M" first="Maryvonne" last="Kombila">Maryvonne Kombila</name>
<name sortKey="Lebibi, Jacques" sort="Lebibi, Jacques" uniqKey="Lebibi J" first="Jacques" last="Lebibi">Jacques Lebibi</name>
<name sortKey="Lekana Douki, Jean Bernard" sort="Lekana Douki, Jean Bernard" uniqKey="Lekana Douki J" first="Jean Bernard" last="Lekana-Douki">Jean Bernard Lekana-Douki</name>
<name sortKey="Oyegue Liabagui, Sandrine Lydie" sort="Oyegue Liabagui, Sandrine Lydie" uniqKey="Oyegue Liabagui S" first="Sandrine Lydie" last="Oyegue Liabagui">Sandrine Lydie Oyegue Liabagui</name>
<name sortKey="Oyegue Liabagui, Sandrine Lydie" sort="Oyegue Liabagui, Sandrine Lydie" uniqKey="Oyegue Liabagui S" first="Sandrine Lydie" last="Oyegue Liabagui">Sandrine Lydie Oyegue Liabagui</name>
<name sortKey="Toure Ndouo, Fousseyni Samba" sort="Toure Ndouo, Fousseyni Samba" uniqKey="Toure Ndouo F" first="Fousseyni Samba" last="Toure Ndouo">Fousseyni Samba Toure Ndouo</name>
<name sortKey="Zatra, Rafika" sort="Zatra, Rafika" uniqKey="Zatra R" first="Rafika" last="Zatra">Rafika Zatra</name>
</country>
<country name="France">
<region name="Île-de-France">
<name sortKey="Druilhe, Pierre" sort="Druilhe, Pierre" uniqKey="Druilhe P" first="Pierre" last="Druilhe">Pierre Druilhe</name>
</region>
</country>
</tree>
</affiliations>
</record>

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